Initiative for Multicenter Pragmatic Anesthesiology Clinical Trials (IMPACT)

This award was established by leaders of academic anesthesiology organizations that recognized there was a need to conduct large pragmatic trials in order to answer important questions in anesthesiology-related research. Although there are several successful anesthesiology clinical trial networks around the world, until now, one did not exist in the United States. In an initial attempt to address this important opportunity, a consortium of academic anesthesiology organizations launched an initiative in 2018 to stimulate pragmatic research in the U.S. in collaboration with our colleagues in Canada, the Canadian Perioperative Anesthesia Clinical Trials Group (PACT), and elsewhere. This effort was conceptualized and endorsed by a few key organizations, which have as a common goal the advancement of knowledge in anesthesiology and the enhancement of care in perioperative medicine, critical care, pain management, and peri- and post-partum care. These organizations included:

These organizations have joined together and established a program to support the development of proposals for pragmatic clinical trials by anesthesiology investigators for submission to external funding sources, such as the NIH. By working together, we believe that we can improve the quality of the proposals and increase the prospects of securing funding. The process includes an opportunity for input and advice from knowledgeable sources, along with a $15,000 grant to support the development of the final proposal.

The process:  The grant cycle opens in October, with Letters of Intent accepted through late November.  The Letter of Intent should outline the personnel, institutions and specific aims of a pragmatic clinical trial in perioperative medicine, see guidelines.  The LOI’s are reviewed by a panel of Anesthesiology experts.  From the pool of LOI’s, six applicants are chosen to write a full proposal.  The six full proposals undergo an additional expert review and three finalists are chosen to receive the $15,000 award.  The award is meant to support the three finalists with the development costs of writing a larger grant, to help increase the likelihood of a major grant award.

Note: The 2019 IMPACT Application period is now closed. The next IMPACT grant cycle will begin in October. Keep an eye on our website for more details.

Past Recipients


Karim Ladha, MD
The Comparison of Analgesic Regimen Effectiveness for Surgery (CARES) Trial
Assistant Professor & Staff Anesthesiologist
Department of Anesthesia and Pain Medicine
University Health Network, Toronto General Hospital

David Mazer, MD
TRICS IV-Restrictive versus Liberal Transfusion in Younger Patients Undergoing Cardiac Surgery
Associate Scientist & Professor
St Michael’s Hospital, Toronto

Robert Schonberger, MD, MHS
Improving population health via the surgical encounter: Targeting underuse of statins
Associate Professor
Yale University – School of Medicine


Michael Aziz, MD
Optimized Opioid Management or Usual Treatment to Reduce Persistent Opioid Use Following Surgery (OPT-OUT).
Anesthesiology & Preoperative Medicine
Oregon Health & Science University

Randall Blank, MD, PhD
Individualized Intraoperative Protective Ventilation using an Open Lung Approach with Driving Pressure Limitation.
Associate Professor of Anesthesiology
Chief, Thoracic Anesthesia
Department of Anesthesiology
University of Virginia Health System

Frederic T. (Josh) Billings IV, MD, MSc
Intraoperative Normoxia versus Hyperoxia during Maintenance Anesthesia to Reduce Postoperative Complications.
Associate Professor of Anesthesiology and Medicine
Co-director, BH Robbins Scholars Physician-Scientist Development Program
Vanderbilt University