SOCCA Researchers Expanding Cold Platelet Knowledge
by Brigid C. Flynn, MD and Matthew Warner, MD
The optimal storage temperature of transfused platelets for surgical and traumatic hemorrhage remains controversial. Standard practice since 1969 has been to transfuse platelets at room temperature (22o). This practice is based on decades old research demonstrating that platelets are removed from the circulation more quickly when stored at 4o than platelets at room temperature.1 Since the most common indication for platelet transfusion is thrombocytopenia due to oncologic disorders in order to prevent bleeding, the increase in circulatory time with room temperature platelets was preferred.
However, the circulatory time of platelets is less important for patients with bleeding where they need to form a clot quickly. Trials in 1973 indicated that cold stored platelets were more hemostatically active than room temperature platelets.2 With more than 30,000 deaths per year in the United States attributable to traumatic bleeding, finding a way to improve platelet transfusion efficacy and availability could save many lives.3 Several potential advantages of cold-stored platelets over room-temperature platelets include: 1) longer storage durations (i.e., 14 days vs. 5-7 days), which minimizes platelet wastage due to outdating; 2) enhanced in vivo hemostatic function; and 3) lower risk of bacterial contamination.4
Members of the SOCCA research committee are aiding in understanding the implications of storage temperature of transfused platelets as investigators on key projects in this field. In anticipation of low inventories, Matthew Warner, MD and colleagues at the Mayo Clinic in Minnesota performed a single-center observational study converting about-to-expire room temperature platelets to cold storage, which extended shelf-life from 5 to 14 days.5 Through the first 45 days of this process, 61 chilled platelet units were transfused to hemorrhaging patients, with 95% transfused for operative bleeding. The researchers reported positive post-transfusion platelet count increments and adequate hemostasis without adverse events.
The CHIlled Platelet Study (CHIPS) is a Phase III, multicenter trial sponsored by the Department of Defense which aims to compare the effectiveness and safety of chilled platelets versus standard room temperature platelets in 1000 bleeding cardiac surgical patients (NCT04834414). Philip Spinella, MD is the primary investigator (PI) contact overseeing more than 20 sites involved in the study with Brigid Flynn, MD acting as site PI for the University of Kansas. The primary outcome for the CHIPS study is bleeding defined by the Universal Bleeding Score with the main secondary outcome being chest tube output. Adaptive trial design methodology is being used to determine the maximum storage duration of chilled platelets for patients with active bleeding. The trial is expected to be completed by January of 2025.
As bleeding affects many critically ill patients, results from ongoing and future studies evaluating the effectiveness, safety, and availability of chilled platelets are highly anticipated.
- Murphy S, et al. N Engl J Med 1969;280:1094-1098.
- Becker GA, et al. Transfusion 1973;13::61-8.
- Spinella PC, et al. Curr Opin Hematol 2017;24:529-535.
- Ketter PM, et al. Transfusion 2019 Apr;59(S2):1479-1489
- Warner MA, et al. Transfusion 2021 Jan;61(1):72-77.
Brigid C. Flynn, MD
Secretary, Society of Critical Care Anesthesiologists
University of Kansas Medical Center
Kansas City, Kansas
Matthew Warner, MD
Chair, Research Committee
SOCCA Reception at 2023 SCCM Critical Care Congress in San Francisco
Time: 5:00 PM – 7:00 PM PT
Location: Hilton Union Square (333 O’Farrell Street)
Room: Franciscan A
When: February 2, 2023 | 6:00 PM ET
Where: Register online
Description: Join us for our first Early Career Intensivist Group Meet and Greet of the year on February 2 at 6pm ET. We will have SOCCA board member Dr. Ashish Khanna joining us for a lively discussion about navigating through life as an Early Career Intensivist. We look forward to seeing you soon!
Mechanical Circulatory Support (MCS) / Extra Corporeal Membrane Oxygenation (ECMO) / Cardio Thoracic ICU (CTICU) Workgroup
Members who have a special interest in MCS are invited to join this workgroup. Our first meeting will be January 19, 2023, at 5PM CST. Please register in advance: SOCCA CTICU/ECMO Meetup Link.
This year, SOCCA is seeking committee volunteers for our communication, education, membership, and research committees—as well as the new clinical practice committee. To view committee descriptions and submit an application, visit https://socca.org/get-involved/.
You may submit an application for a SOCCA Committee between November 1, 2022 and December 31, 2022.
Learn more & review SOCCA’s Volunteer Selection Criteria.
This election cycle, SOCCA will be electing three members for the Board of Directors (3-year term). Further details about the governance structure of SOCCA are described in SOCCA’s Society Bylaws.
SOCCA members interested in serving in an elected positions on the SOCCA Board of Directors should submit a letter of interest, photograph, and curriculum vitae to Vivian Abalama, IOM, CAE ([email protected]) with subject line “2023 SOCCA Board of Directors Election.”
Review criteria by which Board of Directors and volunteer leaders are evaluated: Volunteer Selection Criteria.
You can apply via email only for a Board of Directors position between November 1, 2022 and December 5, 2022.
SOCCA Innovators Award: applications open 9/30/2022 – 12/31/2022.
Gender Equality in Critical Care
Major professional societies & organizations have the obligation to initiate & sustain strategies that support & enhance gender equality in critical care. WICC invites members of SOCCA to participate & discuss ways to advance these goals & values. Understanding & recognizing gender diversity challenges & carrying on the momentum gathered in recent years within SOCCA and outside it, will enable a positive environment for more women to enter & remain within ACCM.
SOCCA has a calendar/list of events. Visit it regularly & save essential dates.
The SOCCA Speakers Bureau has officially launched! As a SOCCA member, you may now:
Have you made any changes in 2022? It’s time to update your SOCCA demographic profile and / or renew your membership. Keep your SOCCA experience seamless & don’t miss out on any updates & member benefits. Visit: buff.ly/3sPMG6j
SOCCA would like to acknowledge the invaluable contributions of our female intensivists during this month and year-round. Throughout September, four of our members will be sharing their experiences as a woman in critical care.
Read: Burnout: No Easy Answers in a Post-Pandemic World, by Sarah Alber, MD
Read: Belonging to an Organization: Professional Advancement & Personal Gains, by Nazish Hashmi, MD
Read: Mentors and Mentees: A Powerful Connection, by May Hua, MD, MS
Read: Women in Critical Care: Where We Are & Where We Want to Be, by Shahla Siddiqui, MD, MSc, FCCM
Shahla Siddiqui, MD, MSc, FCCM, and Co-Chair of SOCCA’s Women in Critical Care recently edited a special issue of Journal of Critical Care featuring women as first and senior authors. Read Dr. Siddiqui’s introduction in Volume 71 | October 2022 issue.
The SOCCA Early Career Intensivists working group provides new members and members who are early in their careers with the resources needed to ease the transition from trainee to practicing intensivist. Learn more.
Have you read “SOCCA, the Pandemic, and the Future” by SOCCA’s Miguel Cobas, MD, FCCM, in this month’s ASA Monitor? Visit: https://socca.org/wp-content/uploads/2022/04/Cobas_SOCCA.pdf
As a SOCCA member, you are eligible to receive a discount on an IARS membership. IARS membership benefits include a subscription to Anesthesia & Analgesia, SOCCA’s official journal, A&A Practice e-journal, free journal CME, access to a member community and discounted registration to the IARS Annual Meeting. Click here to view a list of membership options.
Anesthesiology Critical Care Fellowship Programs
Have you visited SOCCA’s Anesthesiology Critical Care Fellowship Programs page? If you would like your organization’s program added to our site, let us know here: https://socca.org/new-socca-fellowship-listing/.